发明申请
- 专利标题: Carboxylesterase inhibitors
- 专利标题(中): 羧酸酯酶抑制剂
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申请号: US10925367申请日: 2004-08-24
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公开(公告)号: US20050054691A1公开(公告)日: 2005-03-10
- 发明人: Philip Potter , Janice Hyatt , Christopher Morton , Paul Beroza , Komath Damoradan
- 申请人: Philip Potter , Janice Hyatt , Christopher Morton , Paul Beroza , Komath Damoradan
- 申请人地址: US TN Memphis
- 专利权人: St. Jude Children's Research Hospital
- 当前专利权人: St. Jude Children's Research Hospital
- 当前专利权人地址: US TN Memphis
- 主分类号: A61K31/165
- IPC分类号: A61K31/165 ; A61K31/40 ; A61K31/44
摘要:
This disclosure relates to amides, aryl sulphonamides, aryl ureas, and α,β-diketones derivatives useful as carboxylesterase esterase inhibitors. The disclosure is also directed to the use of these compounds as selective human intestinal carboxylesterase inhibitors and insect carboxylesterase inhibitors. The disclosure is also directed to pharmaceutical compositions and pesticide formulations containing these compounds, and to methods for treating or ameliorating the toxic effects following administration of drugs such as cancer therapy drugs, treating or ameliorating the effects of a drug overdose, and to the use of the compounds for increasing the effectiveness of insecticides and pesticides.