Methods and an apparatus for dynamic best fit compilation of mixed mode instructions are provided. In one embodiment, a provided method includes receiving a non-native software instruction at a device, generating a first native software instruction from a first instruction set based on the non-native software instruction, the generation of the first native software instruction occurring at the device, executing the first native software instruction at the device, generating a second native software instruction from a second instruction set based on the non-native software instruction, the generation of the second native software instruction occurring at the device, and executing the second native software instruction at the device.