发明申请
US20050065104A1 Antisense modulation of acyl coenzyme a cholesterol acyltransferase-1 expression
审中-公开
酰基辅酶A反义调节胆固醇酰基转移酶-1表达
- 专利标题： Antisense modulation of acyl coenzyme a cholesterol acyltransferase-1 expression
- 专利标题（中）： 酰基辅酶A反义调节胆固醇酰基转移酶-1表达
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申请号： US10484437申请日： 2002-07-17
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公开(公告)号： US20050065104A1公开(公告)日： 2005-03-24
- 发明人: Rosanne Crooke , Mark Graham , Kristina Tarbet
- 申请人： Rosanne Crooke , Mark Graham , Kristina Tarbet
- 国际申请： PCT/US02/22696 WO 20020717
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C12N15/113 ; A61K48/00 ; C07H21/04
摘要：
Antisense compounds, compositions and methods are provided for modulating the expression of acyl coenzyme A cholesterol acyltransferase-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding acyl coenzyme A cholesterol acyltransferase-1. Methods of using these compounds for modulation of acyl coenzyme A cholesterol acyltransferase-1 expression and for treatment of diseases associated with expression of acyl coenzyme A cholesterol acyltransferase-1 are provided.