发明申请
US20050070507A1 Process for the preparation of 3-amino-2-hydroxypropylphosphinic acid derivatives
有权
3-氨基-2-羟丙基次膦酸衍生物的制备方法
- 专利标题： Process for the preparation of 3-amino-2-hydroxypropylphosphinic acid derivatives
- 专利标题（中）： 3-氨基-2-羟丙基次膦酸衍生物的制备方法
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申请号： US10946869申请日： 2004-09-22
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公开(公告)号： US20050070507A1公开(公告)日： 2005-03-31
- 发明人: Bao-Guo Huang , Witold Subotkowski , Duane Rudisill
- 申请人： Bao-Guo Huang , Witold Subotkowski , Duane Rudisill
- 申请人地址： US NJ Bridgewater
- 专利权人： Aventis Pharmaceuticals Inc.
- 当前专利权人： Aventis Pharmaceuticals Inc.
- 当前专利权人地址： US NJ Bridgewater
- 主分类号： C07F9/30
- IPC分类号： C07F9/30 ; A61K31/66 ; C07F9/28
摘要：
The present invention relates to a process for the preparation of 3-amino-2-hydroxypropylphosphinic acid derivatives of the formula I, which are valuable pharmaceutical active ingredients and can be used, for example, as antidepressants. The process starts from O-ethyl phosphinates of the formula II into which, after silylation with hexamethyldisilazane, the 3-amino-2-hydroxypropyl moiety is introduced by reactions with epichlorohydrin and ammonia.
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