For eigenmode transmission with minimum mean square error (MMSE) receiver spatial processing, a transmitter performs spatial processing on NS data symbol streams with steering vectors to transmit the streams on NS spatial channels of a MIMO channel. The steering vectors are estimates of transmitter steering vectors required to orthogonalize the spatial channels. A receiver derives a spatial filter based on an MMSE criterion and with an estimate of the MIMO channel response and the steering vectors. The receiver (1) obtains NR received symbol streams from NR receive antennas, (2) performs spatial processing on the received symbol streams with the spatial filter to obtain NS filtered symbol streams, (3) performs signal scaling on the filtered symbol streams with a scaling matrix to obtain NS recovered symbol streams, and (4) processes the NS recovered symbol streams to obtain NS decoded data streams for the NS data streams sent by the transmitter.