发明申请
US20050080085A1 Novel 3beta-amino azabicyclooctane heteroaromatic amid derivatives preparation method and therapeutic uses thereof
有权
新型3β-氨基偶氮二异辛烷杂芳族酰胺衍生物的制备方法及其治疗用途
- 专利标题: Novel 3beta-amino azabicyclooctane heteroaromatic amid derivatives preparation method and therapeutic uses thereof
- 专利标题(中): 新型3β-氨基偶氮二异辛烷杂芳族酰胺衍生物的制备方法及其治疗用途
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申请号: US10494639申请日: 2002-10-30
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公开(公告)号: US20050080085A1公开(公告)日: 2005-04-14
- 发明人: Thierry Imbert , Barbara Monse , Wouter Koek
- 申请人: Thierry Imbert , Barbara Monse , Wouter Koek
- 优先权: FR01/14220 20011102
- 国际申请: PCT/FR02/03737 WO 20021030
- 主分类号: A61K31/46
- IPC分类号: A61K31/46 ; A61P25/00 ; C07D491/04 ; C07D491/048 ; C07D495/04 ; C07D519/00 ; C07D491/02 ; A61K31/4741 ; A61K31/4743 ; A61K31/498 ; C07D498/02
摘要:
The invention concerns compounds of general formula 1, wherein: A, B, D and E represent one or two nitrogen atoms, the others being carbon atoms; X represents a S or, a O, thereby forming a bicyclic fused heteroaromatic, such as thieno[2,3-b]pyridine, furo[2,3-b]pyridine, thieno[3,2-b]pyridine, furo[3,2-b]pyridine, thieno[2,3-b]pyrazine, furo[2,3-b]pyrazine, thieno[2,3-c]pyridine, furo[2,3-c]pyridine, thieno[3,2-c]pyridine and furo[3,2-c]pyridine; R1 represents a linear or branched C1-C6 alkoxy group, a linear or branched C1-C6 alkylthio group; R2 represents a linear, branched, cyclic C2-C8 group, a 2- or 3- thienylmethyl group, or a benzyl group optionally substituted by one or several halogens, F, Cl, Br, I, C1-C4 alkyl, C1-C4 alkoxy, CF3, CN, NO2, OH; and their pharmaceutically acceptable salts. Said compounds are anti-dopaminergic agents.