发明申请
US20050080246A1 Compositions comprising alternating 2'-modified nucleosides for use in gene modulation
有权
包含交替的2'-修饰核苷的组合物用于基因调控
- 专利标题： Compositions comprising alternating 2'-modified nucleosides for use in gene modulation
- 专利标题（中）： 包含交替的2'-修饰核苷的组合物用于基因调控
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申请号： US10860265申请日： 2004-06-03
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公开(公告)号： US20050080246A1公开(公告)日： 2005-04-14
- 发明人: Charles Allerson , Balkrishen Bhat , Anne Eldrup , Muthiah Manoharan , Richard Griffey , Brenda Baker , Eric Swayze
- 申请人： Charles Allerson , Balkrishen Bhat , Anne Eldrup , Muthiah Manoharan , Richard Griffey , Brenda Baker , Eric Swayze
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C07H21/02 ; C07H21/04
摘要：
The present invention provides compositions comprising at least one oligomeric compound comprising an alternating motif and further include a region that is complementary to a nucleic acid target. The compositions are useful for targeting selected nucleic acid molecules and modulating the expression of one or more genes. In preferred embodiments the compositions of the present invention hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. The present invention also provides methods for modulating gene expression.
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