发明申请
- 专利标题： 3-Quinolin-2(1h)-ylideneindolin-2-one derivative
- 专利标题（中）： 3-喹啉-2（1h） - 亚基二氢吲哚-2-酮衍生物
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申请号： US10478504申请日： 2002-05-23
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公开(公告)号： US20050090498A1公开(公告)日： 2005-04-28
- 发明人: Kiyohiro Samizu , Hiroyuki Hisamichi , Akira Matsuhisa , Isao Kinoyama , Masahiko Hayakawa , Nobuaki Taniguchi , Yukitaka Ideyama , Sadao Kuromitsu , Kiyoshi Yahiro , Minoru Okada
- 申请人： Kiyohiro Samizu , Hiroyuki Hisamichi , Akira Matsuhisa , Isao Kinoyama , Masahiko Hayakawa , Nobuaki Taniguchi , Yukitaka Ideyama , Sadao Kuromitsu , Kiyoshi Yahiro , Minoru Okada
- 优先权： JP2001-155761 20010524
- 国际申请： PCT/JP02/05014 WO 20020523
- 主分类号： A61P27/02
- IPC分类号： A61P27/02 ; A61P35/00 ; A61P43/00 ; C07D209/34 ; C07D211/22 ; C07D215/12 ; C07D215/60 ; C07D263/10 ; C07D401/04 ; C07D401/12 ; C07D401/14 ; C07D405/12 ; C07D405/14 ; C07D409/14 ; C07D413/14 ; C07D471/04 ; C07D487/04 ; C07D491/10 ; C07D491/113 ; C07D493/04 ; C07D471/02 ; A61K31/4709 ; A61K31/4745 ; A61K31/498 ; A61K31/519
摘要：
There is provided medicaments, particularly a vascular endothelial growth factor (VEGF) inhibitor which is useful as a therapeutic drug for solid tumors, diabetic retinopathy and the like diseases in which angiogenesis is taking a role. That is, since a novel 3-quinolin-2(1H)-ylideneindolin-2-one derivative or a salt thereof has good VEGF inhibitory action, angiogenesis inhibitory action and anti-tumor action, it is useful as ideal VEGF inhibitor, angiogenesis inhibitor and anti-tumor agent.
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