发明申请
US20050090526A1 Substituted coumarins and quinolines and analogs as activators of caspases and inducers of apoptosis and the use thereof
失效
取代的香豆素和喹啉和类似物作为胱天蛋白酶的激活剂和凋亡诱导剂及其用途
- 专利标题： Substituted coumarins and quinolines and analogs as activators of caspases and inducers of apoptosis and the use thereof
- 专利标题（中）： 取代的香豆素和喹啉和类似物作为胱天蛋白酶的激活剂和凋亡诱导剂及其用途
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申请号： US10989057申请日： 2004-11-16
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公开(公告)号： US20050090526A1公开(公告)日： 2005-04-28
- 发明人: Sui Cai , Hong Zhang , William Kemnitzer , Songchun Jiang , John Drewe , Richard Storer
- 申请人： Sui Cai , Hong Zhang , William Kemnitzer , Songchun Jiang , John Drewe , Richard Storer
- 申请人地址： US CA San Diego CA Laval
- 专利权人： Cytovia, Inc.,Shire BioChem, Inc.
- 当前专利权人： Cytovia, Inc.,Shire BioChem, Inc.
- 当前专利权人地址： US CA San Diego CA Laval
- 主分类号： A61K31/35
- IPC分类号： A61K31/35 ; A61K31/385 ; A61K31/47 ; C07D215/54 ; C07D221/10 ; C07D311/16 ; C07D311/58 ; C07D335/06 ; C07D409/04 ; C07D471/04 ; C07D491/04 ; C07D493/04 ; C07D495/04 ; C07D513/04 ; A61K31/366 ; A61K31/382
摘要：
The present invention is directed to substituted coumarins and quinolines and analogs thereof, represented by the general Formula I: wherein A, B, X, Y, and Z are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.