发明申请
- 专利标题： T cell regulatory genes associated with immune disease
- 专利标题（中）： 与免疫疾病相关的T细胞调节基因
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申请号： US10663497申请日： 2003-09-15
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公开(公告)号： US20050095593A1公开(公告)日： 2005-05-05
- 发明人: Jennifer McIntire , Rosemarie Dekruyff , Dale Umetsu , Gordon Freeman
- 申请人： Jennifer McIntire , Rosemarie Dekruyff , Dale Umetsu , Gordon Freeman
- 专利权人： The Board of Trustees of the Leland Stanford Junior University,Dana-Farber Cancer Institute, Inc.
- 当前专利权人： The Board of Trustees of the Leland Stanford Junior University,Dana-Farber Cancer Institute, Inc.
- 主分类号： A61K
- IPC分类号： A61K20060101 ; C07K14/705 ; C12Q1/68
摘要：
A genetic locus and corresponding family of proteins associated with regulation of immune development, function, and cell survival are provided. The locus comprising the TIM family is genetically associated with immune dysfunction, including atopy, autoimmunity, inflammatory bowel disease, dysplasia, and susceptibility to blood-bourne infectious diseases. Polymorphisms in the human TIM-1 gene and exposure to Hepatitis A Virus (HAV) are shown to be associated with protection from the development of atopy.
公开/授权文献
- US07838220B2 T cell regulatory genes associated with immune disease 公开/授权日：2010-11-23
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