发明申请
- 专利标题: Peptide deformylase activated prodrugs
- 专利标题(中): 肽变性酶活化的前药
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申请号: US10511489申请日: 2003-04-17
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公开(公告)号: US20050096254A1公开(公告)日: 2005-05-05
- 发明人: Maria Sergeeva , Venkata Doppalapudi
- 申请人: Maria Sergeeva , Venkata Doppalapudi
- 优先权: US60374089 20020418
- 国际申请: PCT/US03/11981 WO 20030417
- 主分类号: A61K47/48
- IPC分类号: A61K47/48 ; A61K49/00 ; C12Q1/18 ; A61K38/17
摘要:
This invention provides a method for inhibiting the growth of a microorganism that expresses Peptide Deformylase by contacting the microorganism with an effective amount of the compound described herein. This method inhibits the growth of gram-positive and gram-negative microorganism, e.g., S. aureus, S. epidermidis, K. pneumoniae, E. aerogenes, and E. cloacae. This method can be practiced in vitro, ex vivo and in vivo. Further provided is a method for alleviating the symptoms of an infection by a Peptide Deformylase expressing microorganism in a subject by administering or delivering to the subject an effective amount of the compound described above.
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