发明申请
- 专利标题： Stabilized azithromycin compositions
- 专利标题（中）： 稳定的阿奇霉素组合物
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申请号： US10936075申请日： 2004-09-07
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公开(公告)号： US20050106239A1公开(公告)日： 2005-05-19
- 发明人: Ruth Tenengauzer , Joseph Schwarz , Julia Hrakovsky , Tania Lessen , Lev Khondo , Mathi Mathivanan , Claude Singer , Michael Pesachovich
- 申请人： Ruth Tenengauzer , Joseph Schwarz , Julia Hrakovsky , Tania Lessen , Lev Khondo , Mathi Mathivanan , Claude Singer , Michael Pesachovich
- 主分类号： A61K9/00
- IPC分类号： A61K9/00 ; A61K9/14 ; A61K9/16 ; A61K9/20 ; A61K31/353 ; A61K31/375 ; A61K31/70 ; A61K31/7048 ; A61K31/7052 ; A61K47/10
摘要：
Compositions and methods of stabilizing azithromycin compositions are described. Stabilized azithromycin compositions comprise an intimate admixture of azithromycin and a stabilizing-effective amount of an antioxidant to improve the resistance of the azithromycin to degradation. Coprecipitation or co-milling of azithromycin and an antioxidant are particularly preferred means of achieving an intimate admixture. Pharmaceutical formulations comprising a stabilized azithromycin composition and methods of making such formulations are also described.
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