发明申请
- 专利标题： Once-a-day, oral, controlled-release, oxycodone dosage forms
- 专利标题（中）： 每日一次，口服，控释，羟考酮剂型
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申请号： US10977403申请日： 2004-10-28
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公开(公告)号： US20050106249A1公开(公告)日： 2005-05-19
- 发明人: Stephen Hwang , Nishit Modi , Padmaja Shivanand
- 申请人： Stephen Hwang , Nishit Modi , Padmaja Shivanand
- 主分类号： A61K9/00
- IPC分类号： A61K9/00 ; A61K31/485 ; A61K9/26
摘要：
Oxycodone formulations are provided which produce substantially flat in vivo steady state plasma profiles. Tolerance levels associated with such profiles and tolerance levels associated with biphasic profiles are shown not to be statistically different. The substantially flat in vivo steady state plasma profiles are produced by dosage forms having substantially zero order in vitro release profiles. Such release profiles produce low single dose in vivo Cmax levels which can reduce the probability of adverse side effects.
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