An article of footwear comprising a molded unitary support structure preferably constructed of substantially continuous fibers aligned in one or more defined orientations disposed within a hardened resin matrix and methods of manufacturing is disclosed. The unitary support structure comprises a plurality of wall structures including a sole that extends generally from a front end region configured to underlie the toe region of the foot to a back end region configured and side wall structures that extend from the sides of the sole. The wall structures are partitioned from one another to facilitate flex and provide structural and functional independence between partitioned regions. The vertical and longitudinal locations of the partitions are configured to coincide with defined locations relative to the foot so as to facilitate natural movement bending in the foot while also providing the needed support as well as the desired flexibility in attached ground engaging structures. An upper portion overlies and conforms to the wall structures of unitary support structure and extends from its perimeter regions to further encapsulate the foot and provide comfort, fit and performance traditionally obtained from lasted articles of footwear. A preferred method of manufacture includes the steps of forming a male mold, overlaying it with plies of substantially continuous groups of aligned fibers oriented in defined directions to form an uncured pre-form construct of the unitary support structure, which is then cured in a female mold, partitioned and incorporated into an article of footwear. Regions of the wall structures including the sole may be formed to include variations in strength, flexibility and/or elastic modulus in one or more directions.