Invention Application
US20050118140A1 Methods for producing an active constituent of a pharmaceutical or a diagnostic agent in an mdck cell suspension culture
审中-公开
在mdck细胞悬浮培养物中制备药物或诊断剂的活性成分的方法
- Patent Title: Methods for producing an active constituent of a pharmaceutical or a diagnostic agent in an mdck cell suspension culture
- Patent Title (中): 在mdck细胞悬浮培养物中制备药物或诊断剂的活性成分的方法
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Application No.: US10487707Application Date: 2002-09-11
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Publication No.: US20050118140A1Publication Date: 2005-06-02
- Inventor: Jurgen Vorlop , Christian Frech , Holger Lubben , Jens-Peter Gregersen
- Applicant: Jurgen Vorlop , Christian Frech , Holger Lubben , Jens-Peter Gregersen
- Applicant Address: DE Marburg 35041
- Assignee: CHIRON BEHRING GMBH & CO.
- Current Assignee: CHIRON BEHRING GMBH & CO.
- Current Assignee Address: DE Marburg 35041
- Priority: DE10144906.2 20010912
- International Application: PCT/EP02/10208 WO 20020911
- Main IPC: C12P21/02
- IPC: C12P21/02 ; A61K39/00 ; A61K39/12 ; A61K39/39 ; A61K48/00 ; A61P31/12 ; C12N5/06 ; C12N5/10 ; C12N7/00 ; C12N7/02 ; C12N15/867
Abstract:
The present invention concerns a method for production of an active ingredient of a drug or diagnostic agent, in which (a) MDCK cells are infected with a virus; and (b) the MDCK cells are cultured in suspension culture on a commercial scale under conditions that permit multiplication of the viruses; in which culturing occurs in a volume of at least 30 L. The invention also concerns a method for production of a drug or diagnostic agent in which an active ingredient is produced according to the above method and mixed with an appropriate adjuvant, auxiliary, buffer, diluent or drug carrier.
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