发明申请
US20050124672A1 N-phenylarylsulfonamide compound drug containing the compound as active ingredient intermediate for the compound and processes for producing the same
有权
含有化合物作为化合物的活性成分中间体的N-苯基芳基磺酰胺化合物药物及其制备方法
- 专利标题: N-phenylarylsulfonamide compound drug containing the compound as active ingredient intermediate for the compound and processes for producing the same
- 专利标题(中): 含有化合物作为化合物的活性成分中间体的N-苯基芳基磺酰胺化合物药物及其制备方法
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申请号: US10471673申请日: 2002-03-11
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公开(公告)号: US20050124672A1公开(公告)日: 2005-06-09
- 发明人: Atsushi Naganawa , Tetsuji Saito , Kaoru Kobayashi , Takayuki Maruyama , Yoshihiko Nakai , Shinsuke Hashimoto
- 申请人: Atsushi Naganawa , Tetsuji Saito , Kaoru Kobayashi , Takayuki Maruyama , Yoshihiko Nakai , Shinsuke Hashimoto
- 优先权: JP2001-68498 20010312; JP2001-281569 20010917; JP2002-7760 20020116
- 国际申请: PCT/JP02/02245 WO 20020311
- 主分类号: C07D307/64
- IPC分类号: C07D307/64 ; A61K31/34 ; A61K31/341 ; A61K31/41 ; A61K31/4245 ; A61K31/426 ; A61K31/427 ; A61K31/4402 ; A61K31/4406 ; A61K31/4439 ; A61P1/04 ; A61P13/00 ; A61P13/02 ; A61P29/00 ; A61P35/00 ; A61P43/00 ; C07D213/70 ; C07D213/71 ; C07D277/20 ; C07D277/36 ; C07D401/12 ; C07D405/12 ; C07D413/12 ; C07D417/12
摘要:
An N-phenylarylsulfonylamide compound of formula (I) (R1 is COOH etc.; R2 is hydrogen, methyl, etc.; R3 and R4 are a combination of methyl and methyl, etc.; R5 is isopropyl etc.; Ar is thiazolyl, pyridyl, 5-methyl-2-furyl each optionally substituted with methyl; n is zero or 1), a synthetic intermediate for the compound and a process for its preparation. The compound of formula (I) binds to a prostaglandin E2 receptor, especially an EP1 subtype receptor, and antagonizes it. It is less affected by protein binding, so it has a satisfactory in vivo activity. Therefore, it is considered to be useful as an analgesic, an antipyretic agent, an agent for the treatment of pollakiuria (frequent urination) and/or lower urinary tract disease syndrome or an antineoplastic agent.
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