An over-current protection device includes a current-sensitive element, two insulating layers and two electrode layers. The current-sensitive element comprises two electrode foils and a current-sensitive layer laminated between the two electrode foils, where the current-sensitive layer has the behavior of positive temperature coefficient. The two insulating layers are stacked on the upper and lower surfaces of the current-sensitive element, respectively, and the glass switching temperature thereof is between 90-120° C. or the heat dissipation rate is between 1-7W/° C.-m. The two electrode layers are connected to the two ends of the current-sensitive element, respectively.