发明申请
US20050130985A1 8-(piperazin-1yl)- and 8-([1,4]diazepan-1yl)-xanthines, the preparation thereof and their use as pharmaceutical composition
有权
8-（哌嗪-1-基） - 和8 - （[1,4]二氮杂环庚烷-1-基） - 黄嘌呤，其制备及其作为药物组合物的用途
![8-(piperazin-1yl)- and 8-([1,4]diazepan-1yl)-xanthines, the preparation thereof and their use as pharmaceutical composition](/docs/US/2005-06-16/US20050130985A1/abs.jpg.600x600.jpg)
- 专利标题： 8-(piperazin-1yl)- and 8-([1,4]diazepan-1yl)-xanthines, the preparation thereof and their use as pharmaceutical composition
- 专利标题（中）： 8-（哌嗪-1-基） - 和8 - （[1,4]二氮杂环庚烷-1-基） - 黄嘌呤，其制备及其作为药物组合物的用途
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申请号： US10979468申请日： 2004-11-02
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公开(公告)号： US20050130985A1公开(公告)日： 2005-06-16
- 发明人: Frank Himmelsbach , Elke Langkopf , Matthias Eckhardt , Mohammad Tadayyon , Leo Thomas
- 申请人： Frank Himmelsbach , Elke Langkopf , Matthias Eckhardt , Mohammad Tadayyon , Leo Thomas
- 申请人地址： DE Ingelheim
- 专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人地址： DE Ingelheim
- 优先权： DE10355304 20031127
- 主分类号： A61K31/522
- IPC分类号： A61K31/522 ; C07D473/04 ; C07D519/00
![8-(piperazin-1yl)- and 8-([1,4]diazepan-1yl)-xanthines, the preparation thereof and their use as pharmaceutical composition](/abs-image/US/2005/06/16/US20050130985A1/abs.jpg.150x150.jpg)
摘要：
The present invention relates to substituted xanthines of the general formula in which R1 to R3 and n are as defined in claims 1 to 8, their tautomers, their enantiomers, their diastereomers, their mixtures, their prodrugs and their salts, which have valuable pharmacological properties, in particular an inhibitory action on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).