发明申请
- 专利标题： Hydronopol derivatives as agonists on human ORL1 receptors
- 专利标题（中）： 水诺酮衍生物作为人类ORL1受体的激动剂
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申请号： US11007255申请日： 2004-12-09
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公开(公告)号： US20050131004A1公开(公告)日： 2005-06-16
- 发明人: Matthias Mentzel , Dania Reiche , Reinhard Bruckner , Samuel David , Bartholomeus Van Steen , Uwe Schon , Daniel Jasserand , Ulf Preuschoff
- 申请人： Matthias Mentzel , Dania Reiche , Reinhard Bruckner , Samuel David , Bartholomeus Van Steen , Uwe Schon , Daniel Jasserand , Ulf Preuschoff
- 专利权人： SOLVAY PHARMACEUTICALS GmbH.
- 当前专利权人： SOLVAY PHARMACEUTICALS GmbH.
- 优先权： EP03104662.6 20031212
- 主分类号： A61K31/438
- IPC分类号： A61K31/438 ; A61K31/4747 ; A61P9/06 ; A61P9/12 ; A61P29/00 ; C07D221/00 ; C07D233/00 ; C07D471/10 ; C07D487/08
摘要：
The invention relates to a group of hydronopol derivatives which are agonists on human ORL1 (nociceptin) receptors. The invention also relates to the preparation of these compounds, to pharmaceutical compositions containing a pharmacologically active amount of at least one of these novel hydronopol derivatives as an active ingredient, as well as to the use of these pharmaceutical compositions for the treatment of disorders in which ORL1 receptors are involved. The invention relates to compounds of the general formula (1) wherein the symbols have the meanings as given in the description.
公开/授权文献
- US07241770B2 Hydronopol derivatives as agonists on human ORL1 receptors 公开/授权日：2007-07-10