发明申请
- 专利标题： Compounds capable of activating cholinergic receptors
- 专利标题（中）： 能够激活胆碱能受体的化合物
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申请号： US11048212申请日： 2005-02-01
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公开(公告)号： US20050131034A1公开(公告)日： 2005-06-16
- 发明人: William Caldwell , Gary Dull , Balwinder Bhatti , Srishailkumar Hadimani , Haeil Park , Jared Wagner , Peter Crooks
- 申请人： William Caldwell , Gary Dull , Balwinder Bhatti , Srishailkumar Hadimani , Haeil Park , Jared Wagner , Peter Crooks
- 主分类号： A61K31/44
- IPC分类号： A61K31/44 ; A61K31/505 ; C07D213/38 ; C07D213/61 ; C07D213/65 ; C07D213/73 ; C07D239/26 ; A61K31/70 ; C07D213/24
摘要：
Compounds incorporating aryl substituted olefinic amine are provided. Representative compounds are (4E)-N-methyl-5-(3-pyridyl)4-penten-2-amine, (4E)-N-methyl-5-(5-pyrimidinyl)4-penten-2-amine, (4E)-N-methyl-5-(5-methoxy-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(6-amino-5-methyl-3-pyridyl)-4-penten-2-amine, (2R)-(4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (2R)-(4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-bromo-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-ethoxy-3-pyridyl)-4-penten-2-amine, (2S)-(4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine and (2S)-(4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine.
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