发明申请
US20050137209A1 Treatment of neurologic disorders with inhibitors of 11beta-HSD1
审中-公开
用11beta-HSD1抑制剂治疗神经障碍
- 专利标题: Treatment of neurologic disorders with inhibitors of 11beta-HSD1
- 专利标题(中): 用11beta-HSD1抑制剂治疗神经障碍
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申请号: US11016387申请日: 2004-12-17
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公开(公告)号: US20050137209A1公开(公告)日: 2005-06-23
- 发明人: Donna Oksenberg , Mehrdad Shamloo , Roman Urfer
- 申请人: Donna Oksenberg , Mehrdad Shamloo , Roman Urfer
- 专利权人: AGY Therapeutics, Inc.
- 当前专利权人: AGY Therapeutics, Inc.
- 主分类号: A61K31/496
- IPC分类号: A61K31/496
摘要:
Methods and compositions for the treatment of neurologic disorders involving neuronal death, including but not limited to focal or global ischemia of the brain and central nervous system. In vivo inhibition of 11 beta hydroxysteroid dehydrogenase 1 (HSD1) is shown to be neuroprotective in these conditions. HSD1 inhibitors are administered alone or in combination with additional agents for prophylaxis or therapy.