发明申请
US20050147591A1 Methods and compositions for viral enhancement of cell killing
审中-公开
病毒增强细胞杀伤的方法和组合物
- 专利标题： Methods and compositions for viral enhancement of cell killing
- 专利标题（中）： 病毒增强细胞杀伤的方法和组合物
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申请号： US10946365申请日： 2004-09-21
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公开(公告)号： US20050147591A1公开(公告)日： 2005-07-07
- 发明人: Dennis Hallahan , Ralph Weichselbaum , Donald Kufe , Gregory Sibley , Bernard Roizman
- 申请人： Dennis Hallahan , Ralph Weichselbaum , Donald Kufe , Gregory Sibley , Bernard Roizman
- 主分类号： A61K51/00
- IPC分类号： A61K51/00 ; A61K31/00 ; A61K31/40 ; A61K31/70 ; A61K35/761 ; A61K35/763 ; A61K45/00 ; A61K48/00 ; A61N5/10 ; A61P35/00 ; C12Q1/70 ; C12N15/869
摘要：
The present invention is directed to novel methods of enhancing the effectiveness of DNA damaging agents by exposing cells to viruses prior to or during exposure to the damaging agent. In certain embodiments of the invention, the DNA damaging agent is ionizing radiation, the virus is an adenovirus, and the increase in cell killing is synergistic when compared to radiation alone.
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