发明申请
US20050153986A1 Di-aryl substituted tetrazole modulators of metabotropic glutamate receptor-5
有权
代谢型谷氨酸受体-5的二芳基取代四唑调节剂
- 专利标题: Di-aryl substituted tetrazole modulators of metabotropic glutamate receptor-5
- 专利标题(中): 代谢型谷氨酸受体-5的二芳基取代四唑调节剂
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申请号: US10506479申请日: 2003-03-07
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公开(公告)号: US20050153986A1公开(公告)日: 2005-07-14
- 发明人: Chixu Chen , Nicholas Cosford , Brian Eastman , Dehua Huang , Steve Poon , Thomas Reger , Jeffrey Roppe , Nicholas Smith
- 申请人: Chixu Chen , Nicholas Cosford , Brian Eastman , Dehua Huang , Steve Poon , Thomas Reger , Jeffrey Roppe , Nicholas Smith
- 国际申请: PCT/US03/07074 WO 20030307
- 主分类号: A61K31/4439
- IPC分类号: A61K31/4439 ; A61K31/444 ; A61K31/4709 ; A61K31/506 ; A61K31/5377 ; A61P25/00 ; A61P25/04 ; A61P25/18 ; A61P25/22 ; A61P25/24 ; A61P25/28 ; A61P25/34 ; C07D401/04 ; C07D401/14 ; C07D405/14 ; C07D409/14 ; C07D413/14 ; C07D417/14 ; C07D471/04 ; C07D43/02 ; C07D43/14
摘要:
Tetrazole compounds substituted directly, or by a bridge, with i) a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl and ii) another heteroaryl or aryl ring, with at least one of the rings being further substituted with another ring, are mGluR5 modulators useful in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, panic, and bipolar disorder, as well as in the treatment of pain, Parkinson's disease, cognitive dysfunction, epilepsy, circadian rhythm disorders, drug addiction, drug abuse, drug withdrawal, obesity and other diseases.