发明申请
- 专利标题: 5-Ht2b receptor antagonists
- 专利标题(中): 5-Ht2b受体拮抗剂
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申请号: US10504538申请日: 2003-02-11
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公开(公告)号: US20050154031A1公开(公告)日: 2005-07-14
- 发明人: Alexander Oxford , Richard Borman , Robert Coleman , Kenneth Clark
- 申请人: Alexander Oxford , Richard Borman , Robert Coleman , Kenneth Clark
- 优先权: JP0203413.0 20020213
- 国际申请: PCT/GB03/00567 WO 20030211
- 主分类号: C07D277/20
- IPC分类号: C07D277/20 ; A61K31/425 ; A61K31/426 ; A61P1/00 ; A61P43/00 ; C07D277/40
摘要:
The present invention concerns compounds of formula (I): wherein R1 is selected from the group consisting of H, and optionally substituted C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-C1-4 alkyl, and phenyl-C1-4 alkyl; R2 and R3 are either: (i) independently selected from H, R, R′, SO2R, C(═O)R, (CH2)nNR5R6, where n is from 1 to 4 and R5 and R6 are independently selected from H and R, where R is optionally substituted C1-4 alkyl group, and R′ is an optionally substituted phenyl-C1-4 alkyl group, or (ii) together with the nitrogen atom to which they are attached, form an optionally substituted C5-7 heterocyclic group; R4 is an optionally substituted C9-14 aryl group; their use as pharmaceuticals, in particular for treating conditions alleviated by antagonism of a 5-HT2B receptor.