发明申请
- 专利标题: Preparation of small crystals
- 专利标题(中): 制备小晶体
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申请号: US10513153申请日: 2003-04-08
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公开(公告)号: US20050155541A1公开(公告)日: 2005-07-21
- 发明人: Linda McCausland , David Reay
- 申请人: Linda McCausland , David Reay
- 优先权: WOPCT/GB02/02006 20020502; GB0219815.8 20020824
- 国际申请: PCT/GB03/01540 WO 20030408
- 主分类号: F26B17/10
- IPC分类号: F26B17/10 ; A61K9/16 ; B01D1/18 ; B01D9/00 ; B01D9/02 ; C07D499/18 ; C07D499/46 ; F26B3/12 ; C30B1/00
摘要:
Small crystals are made by mixing a solution of a desired substance with an anti-solvent in a fluidic vortex mixer in which the residence time is less than 1s, for example 10 ms. The liquid within the fluidic vortex mixer (12) is subjected to high intensity ultrasound from a transducer (20, 22). The solution very rapidly becomes supersaturated, and the ultrasound can induce a very large number of nuclei for crystal growth. Small crystals, for example less than 5 μm, are formed. The resulting suspension is treated so as to add or remove ingredients, and then spray dried using an atomiser tuned to create small droplets in such a way that each droplet should contain not more than one crystal. Crystal agglomeration is hence prevented.
公开/授权文献
- US07326294B2 Preparation of small crystals 公开/授权日:2008-02-05