发明申请
US20050159339A1 Pegylated non-hypertensive hemoglobins, methods of preparing same, and uses thereof
有权
聚乙二醇化非高血压血红蛋白，其制备方法及其应用
- 专利标题： Pegylated non-hypertensive hemoglobins, methods of preparing same, and uses thereof
- 专利标题（中）： 聚乙二醇化非高血压血红蛋白，其制备方法及其应用
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申请号： US10957200申请日： 2004-10-01
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公开(公告)号： US20050159339A1公开(公告)日： 2005-07-21
- 发明人: Seetharama Acharya , Paul Smith , Belur Manjula
- 申请人： Seetharama Acharya , Paul Smith , Belur Manjula
- 主分类号： C07C331/28
- IPC分类号： C07C331/28 ; C08B15/06 ; C08B31/00 ; C08B37/00 ; C08B37/02 ; C07K14/805 ; A61K38/42
摘要：
The present invention provides pegylated hemoglobins comprising a thiocarbamoyl-phenyl-polyethylene glycol (PEG) attached to hemoglobin, and comprising a polyethylene glycol (PEG) attached to hemoglobin by an acyl group. The invention also provides methods of preparing pegylated hemoglobins using isothiocyanato phenyl carbamate of PEG and using isothiocyanato phenyl di-PEG carbamate. The invention further provides compositions and blood substitutes comprising pegylated hemoglobins and methods of treating a subject which comprise administering to the subject blood substitutes comprising non-hypertensive pegylated hemoglobins.
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