发明申请
US20050159424A1 Aryl-substituted pyrazole-amide compounds useful as kinase inhibitors
有权
用作激酶抑制剂的芳基取代的吡唑酰胺化合物
- 专利标题： Aryl-substituted pyrazole-amide compounds useful as kinase inhibitors
- 专利标题（中）： 用作激酶抑制剂的芳基取代的吡唑酰胺化合物
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申请号： US10838129申请日： 2004-05-03
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公开(公告)号： US20050159424A1公开(公告)日： 2005-07-21
- 发明人: Alaric Dyckman , Jagabandhu Das , Katerina Leftheris , Chunjian Liu , Rulin Zhao , Bang-Chi Chen , Stephen Wrobleski
- 申请人： Alaric Dyckman , Jagabandhu Das , Katerina Leftheris , Chunjian Liu , Rulin Zhao , Bang-Chi Chen , Stephen Wrobleski
- 主分类号： A61K
- IPC分类号： A61K20060101 ; A61K31/415 ; A61K31/4152 ; A61K31/4155 ; A61K31/416 ; A61K31/4439 ; A61K31/497 ; A61K31/501 ; A61K31/506 ; A61K31/535 ; A61K31/675 ; C07D20060101 ; C07D231/04 ; C07D231/14 ; C07D231/18 ; C07D401/04 ; C07D401/12 ; C07D403/04 ; C07D405/12 ; C07D413/12 ; C07D413/14 ; C07D43/04
摘要：
The present invention relates to compounds having the formula, and pharmaceutically-acceptable salts, prodrugs, solvates, isomers, and/or hydrates thereof, wherein Q is an optionally-substituted phenyl, pyridyl, pyridazinyl, pyrimidinyl, or pyrazinyl ring; R2 is alkyl or an amino group as defined herein; and Z is optionally-substituted oxadiazolyl or —C(═O)NR6, wherein R6 is lower alkyl or cyclopropyl. The compounds are surprisingly advantageous in preparing pharmaceutical compositions for treating p38 kinase related conditions and/or in methods of treating conditions associated with the activity of p38 kinase in a patient.