- 专利标题： Modified chimeric polypeptides with improved pharmacokinetic properties and methods of making and using thereof
-
申请号： US11016097申请日： 2004-12-17
-
公开(公告)号： US20050163798A1公开(公告)日： 2005-07-28
- 发明人: Nicholas Papadopoulos , Samuel Davis , George Yancopoulos
- 申请人： Nicholas Papadopoulos , Samuel Davis , George Yancopoulos
- 专利权人： Regeneron Pharmaceuticals, Inc.
- 当前专利权人： Regeneron Pharmaceuticals, Inc.
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07K14/71 ; C07H21/04 ; A61K39/00
摘要：
Modified chimeric polypeptides with improved pharmacokinetics are disclosed. Specifically, modified chimeric Flt1 receptor polypeptides that have been modified in such a way as to improve their pharmacokinetic profile are disclosed. Also disclosed are methods of making and using the modified polypeptides including but not limited to using the modified polypeptides to decrease or inhibit plasma leakage and/or vascular permeability in a mammal.
公开/授权文献
信息查询
IPC分类:
