发明申请
- 专利标题： Modulation of gene expression using DNA-RNA hybrids
- 专利标题（中）： 使用DNA-RNA杂交体调控基因表达
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申请号： US10793425申请日： 2004-03-04
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公开(公告)号： US20050164212A1公开(公告)日： 2005-07-28
- 发明人: Todd Hauser , Aaron Loomis , David Hensel
- 申请人： Todd Hauser , Aaron Loomis , David Hensel
- 主分类号： A61K31/675
- IPC分类号： A61K31/675 ; A61K38/00 ; C07H21/02 ; C12N15/11 ; C12Q1/68
摘要：
The present invention is directed to novel DNA-RNA hybrids comprising either a DNA sense strand and an RNA antisense strand, or an RNA sense strand and a DNA antisense strand. The compounds of the invention, and compositions and arrays comprising the same, may be used for a variety of purposes, including inhibiting gene expression, treating disease and infection, determining the function of genes, and identifying and validating novel drugs and their targets.
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