发明申请
- 专利标题: Cyclic diamine compound and pharmaceutical containing the same
- 专利标题(中): 环状二胺化合物和含有它的药物
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申请号: US10763241申请日: 2004-01-26
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公开(公告)号: US20050165026A1公开(公告)日: 2005-07-28
- 发明人: Kimiyuki Shibuya , Toru Miura
- 申请人: Kimiyuki Shibuya , Toru Miura
- 申请人地址: JP Nagoya-shi
- 专利权人: Kowa Co., Ltd.
- 当前专利权人: Kowa Co., Ltd.
- 当前专利权人地址: JP Nagoya-shi
- 主分类号: C07D263/58
- IPC分类号: C07D263/58 ; A61K31/496 ; C07D413/02 ; C07F7/04
摘要:
The present invention relates to 2-[4-[2-(7-trifluoromethylbenzoxazol-2-ylthio)ethyl]piperazin-1-yl]-N-[4-hydroxy-2,6-bis(trifluoromethyl)phenyl]acetamide or salt thereof, and an intermediate for the preparation thereof. The above-described compound has both an inhibitory action on ACAT in the artery wall and remarkably high metabolic resistance in human liver microsomes, and exhibits excellent effects for suppressing lipids depression in aorta in vivo so that it is useful as a highly effective preventive or remedy for hyperlipidemia and arteriosclerosis with less side effects.