发明申请
US20050165218A1 Crystal structure of the ligand binding domain of the retinoic acid-related orphan receptor alpha (ror-alpha)
审中-公开
视黄酸相关孤儿受体α（ror-α）的配体结合结构域的晶体结构
- 专利标题： Crystal structure of the ligand binding domain of the retinoic acid-related orphan receptor alpha (ror-alpha)
- 专利标题（中）： 视黄酸相关孤儿受体α（ror-α）的配体结合结构域的晶体结构
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申请号： US10509316申请日： 2003-04-28
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公开(公告)号： US20050165218A1公开(公告)日： 2005-07-28
- 发明人: Rene Beerli , Brigitte Fournier , Jorg Kallen , Jean-Marc Schlaeppi
- 申请人： Rene Beerli , Brigitte Fournier , Jorg Kallen , Jean-Marc Schlaeppi
- 优先权： US60376427 20020429
- 国际申请： PCT/EP03/04433 WO 20030428
- 主分类号： C07K14/705
- IPC分类号： C07K14/705 ; A61K38/47 ; G01N33/48 ; G01N33/50 ; G06F19/00
摘要：
The present invention relates RORa in crystallized form and methods for the preparation thereof. The invention also provides a three-dimensional model of RORa and means for the design of RORa modulators. Ligands binding to RORa are also provided.