A method for computing volumetric perfusion using a computed tomography imaging (CT) system is presented. The method includes irradiating a spatially dynamic object within a field of view of the computed tomography imaging system for requisite view angle positions of the gantry. Furthermore, the method includes operating the computed tomography imaging system in a continuous data acquisition mode to acquire projection data representative of the spatially dynamic object. In addition, the method includes processing the projection data to generate time-resolved projection data. Reconstructions are generated using the time-resolved projection data. Additionally, the method includes computing the volumetric perfusion in the spatially dynamic object using the reconstructed data. Computer-readable medium that afford functionality of the type defined by this method is also contemplated in conjunction with the present technique.