发明申请
US20050171093A1 New piperazin-1-yl and 2-([1,4]diazepan-1-yl)-imidazo[4,5-d]-pyridazin-4-ones, the preparation thereof and their use as pharmaceutial compositions
有权
新的哌嗪-1-基和2 - （[1,4]二氮杂环庚烷-1-基） - 咪唑并[4,5-d] - 哒嗪-4-酮的制备及其作为药物组合物的用途
![New piperazin-1-yl and 2-([1,4]diazepan-1-yl)-imidazo[4,5-d]-pyridazin-4-ones, the preparation thereof and their use as pharmaceutial compositions](/docs/US/2005-08-04/US20050171093A1/abs.jpg.600x600.jpg)
- 专利标题： New piperazin-1-yl and 2-([1,4]diazepan-1-yl)-imidazo[4,5-d]-pyridazin-4-ones, the preparation thereof and their use as pharmaceutial compositions
- 专利标题（中）： 新的哌嗪-1-基和2 - （[1,4]二氮杂环庚烷-1-基） - 咪唑并[4,5-d] - 哒嗪-4-酮的制备及其作为药物组合物的用途
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申请号： US11016176申请日： 2004-12-17
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公开(公告)号： US20050171093A1公开(公告)日： 2005-08-04
- 发明人: Matthias Eckhardt , Norbert Hauel , Frank Himmelsbach , Iris Kauffman-Hefner , Elke Langkopf , Mohammad Tadayyon , Leo Thomas
- 申请人： Matthias Eckhardt , Norbert Hauel , Frank Himmelsbach , Iris Kauffman-Hefner , Elke Langkopf , Mohammad Tadayyon , Leo Thomas
- 申请人地址： DE Ingelheim
- 专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人地址： DE Ingelheim
- 优先权： DE10359098.6 20031217
- 主分类号： A61K31/503
- IPC分类号： A61K31/503 ; A61K31/5377 ; A61K31/551 ; C07D487/02 ; C07D487/04
![New piperazin-1-yl and 2-([1,4]diazepan-1-yl)-imidazo[4,5-d]-pyridazin-4-ones, the preparation thereof and their use as pharmaceutial compositions](/abs-image/US/2005/08/04/US20050171093A1/abs.jpg.150x150.jpg)
摘要：
The present invention relates to substituted imidazo[4,5-d]pyridazin-4-ones of general formula wherein R1 to R3 and n are defined as in claims 1 to 8, the tautomers, enantiomers, diastereomers, mixtures thereof and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).