发明申请
- 专利标题： Compositions inhibiting rejection in organ transplantation and method of using the same
- 专利标题（中）： 组织抑制器官移植排斥反应及其使用方法
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申请号： US10496332申请日： 2002-11-20
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公开(公告)号： US20050175539A1公开(公告)日： 2005-08-11
- 发明人: Ryuichi Morishita , Naruya Tomita , Toshio Ogihara , Haruhito Azuma
- 申请人： Ryuichi Morishita , Naruya Tomita , Toshio Ogihara , Haruhito Azuma
- 优先权： JP2001-358587 20011122
- 国际申请： PCT/JP02/12142 WO 20021120
- 主分类号： A61K31/7088
- IPC分类号： A61K31/7088 ; A61K48/00 ; A61K49/22 ; A61P37/06 ; A61P43/00 ; A61K38/17 ; A61K49/00
摘要：
A novel and effective strategy for organ transplantation is provided. A therapeutic agent and method for preventing an acute rejection in a transplanted organ and improving prognosis are provided. A therapeutic agent for suppressing a rejection in organ transplantation, which comprises an NF-κB decoy compound, is provided. Representatively, the organ transplantation is kidney transplantation. The therapeutic agent further comprises an ultrasonic inspection contrast agent. A therapeutic agent for improving prognosis in organ transplantation is also provided. The therapeutic agent is administered into a donor organ. The transfection efficiency of the NF-κB decoy compound into the organ may be enhanced by ultrasound treatment.
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