The present invention features a non-invasive system and method for delivering apolipoprotein, amphipathic compounds, and the like into the blood stream using pulmonary delivering. Apolipoprotein, amphipathic compounds, and the like is suspended in a solvent, preferably a saline solution. Next, the soluation is nebulized to form a plurality of droplets sized to reach the periphery of the lung. Once proximate the lung, the apolipoprotein, amphipathic compounds, and the like is dissolved through the lung interface and into the serum. Due to its physical and chemical properties, apolipoprotein A-I is effectively absorbed into the serum through the lung. The present invention can be used for the treatment of cardiovascular disease as well Alzheimer's Disease and other.