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发明申请
US20050176730A1 Amide and urea derivatives as 5-HT reuptake inhibitors and as 5-HT 1B/1D ligands 审中-公开
酰胺和脲衍生物作为5-HT再摄取抑制剂和5-HT 1B / 1D配体

Amide and urea derivatives as 5-HT reuptake inhibitors and as 5-HT 1B/1D ligands
摘要：
Amide and urea derivatives of the formula I R1—(CH2)n—(Y)q-(Z)r-CO—NH—R2   (I) in which R1, n, Y, q, Z, r and R2 have the meanings indicated in claim 1, are potent 5-HT1B/1D antagonists and exhibit 5-HT reuptake-inhibiting actions and are suitable for the treatment and prophylaxis of anxiety states, depressions, schizophrenia, compulsive ideas, tardive dyskinesias, learning disorders, age-dependent memory disorders, for positively affecting obsessive-compulsive behaviour (OCD), and also for the treatment and for the control of the sequelae of cerebral infarcts such as stroke and cerebral ischaemias.
摘要（中）：

式I的酰胺和脲衍生物<？in-line-formula description =“In-line Formulas”end =“lead”？> R 1 - （CH 2） ） - （Y）q - （Z）-NR-CO-NH-R 2（I） 其中R 1，N，Y，q，Z，r和R 2中的<？in-line-formula description =“In-line Formulas”end =“tail”？> / SUP>具有权利要求1所述的含义，是有效的5-HT 1B / 1D拮抗剂，并表现出5-HT再摄取抑制作用，并且适用于治疗和预防焦虑状态，沮丧， 精神分裂症，强迫性思想，迟发性运动障碍，学习障碍，年龄依赖性记忆障碍，积极影响强迫症行为（OCD），以及治疗和控制脑梗死后遗症如卒中和脑局部缺血。

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