发明申请
- 专利标题： 3-Substituted quinuclidines and their use
- 专利标题（中）： 3-取代的奎宁和它们的用途
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申请号： US10512570申请日： 2003-05-27
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公开(公告)号： US20050176756A1公开(公告)日： 2005-08-11
- 发明人: Dan Peters , Gunnar Olsen , Elsebet Nielsen , Philip Ahring , Tino Jorgensen
- 申请人： Dan Peters , Gunnar Olsen , Elsebet Nielsen , Philip Ahring , Tino Jorgensen
- 申请人地址： DK Ballerup DK-2750
- 专利权人： NeuroSearch A/S
- 当前专利权人： NeuroSearch A/S
- 当前专利权人地址： DK Ballerup DK-2750
- 优先权： DKPA200200834 20020530
- 国际申请： PCT/DK03/00354 WO 20030527
- 主分类号： A61K31/439
- IPC分类号： A61K31/439 ; A61P1/04 ; A61P1/12 ; A61P1/14 ; A61P3/02 ; A61P3/04 ; A61P5/14 ; A61P5/24 ; A61P9/06 ; A61P9/10 ; A61P9/12 ; A61P11/06 ; A61P15/00 ; A61P15/06 ; A61P15/10 ; A61P17/02 ; A61P17/10 ; A61P21/00 ; A61P21/02 ; A61P21/04 ; A61P25/00 ; A61P25/02 ; A61P25/06 ; A61P25/08 ; A61P25/14 ; A61P25/16 ; A61P25/18 ; A61P25/22 ; A61P25/24 ; A61P25/28 ; A61P25/32 ; A61P25/34 ; A61P25/36 ; A61P27/02 ; A61P29/00 ; A61P31/18 ; A61P35/00 ; A61P37/04 ; A61P43/00 ; C07D453/02 ; A61K31/4745 ; C07D453/04
摘要：
This invention relates to novel 3-substituted quinuclidine derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neurodegeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
公开/授权文献
- US07332507B2 3-substituted quinuclidines and their use 公开/授权日：2008-02-19
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