发明申请
- 专利标题： Tetrahydroisoquinolinyl derivatives of quinazoline and isoquinoline
- 专利标题（中）： 喹唑啉和异喹啉的四氢异喹啉衍生物
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申请号： US11062133申请日： 2005-02-18
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公开(公告)号： US20050182079A1公开(公告)日： 2005-08-18
- 发明人: Martin Allen , Thomas Chappie , John Humphrey , Spiros Liras
- 申请人： Martin Allen , Thomas Chappie , John Humphrey , Spiros Liras
- 专利权人： Pfizer Inc
- 当前专利权人： Pfizer Inc
- 主分类号： C07D401/04
- IPC分类号： C07D401/04 ; C07D491/04 ; A61K31/517 ; C07D43/02
摘要：
The invention pertains to substituted quinazoline and isoquinoline compounds that serve as effective phosphodiesterase (PDE) inhibitors. In particular, the invention relates to said compounds which are selective inhibitors of PDE-10. The invention also relates to intermediates for preparation of said compounds; pharmaceutical compositions comprising said compounds; and the use of said compounds in a method for treating certain central nervous system (CNS) or other disorders.
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