发明申请
- 专利标题: Novel protein and DNA thereof
- 专利标题(中): 新型蛋白质及其DNA
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申请号: US11088999申请日: 2005-03-24
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公开(公告)号: US20050186618A1公开(公告)日: 2005-08-25
- 发明人: Koji Yoshimura , Yuichi Hikichi , Atsushi Nishimura
- 申请人: Koji Yoshimura , Yuichi Hikichi , Atsushi Nishimura
- 申请人地址: JP Osaka
- 专利权人: Takeda Chemical Industries, Ltd.
- 当前专利权人: Takeda Chemical Industries, Ltd.
- 当前专利权人地址: JP Osaka
- 优先权: JP10-250115 19980309
- 主分类号: C07K16/40
- IPC分类号: C07K16/40 ; C12N1/21 ; C12N9/64 ; C12N15/12 ; C12P21/08 ; C12Q1/68 ; A61K48/00 ; C07H21/04
摘要:
The present invention relates to a novel protein belonging to an ADAM family, a partial peptide thereof or a salt thereof, a DNA encoding the protein, a recombinant vector comprising the DNA, a transformant, a method for producing the protein, a medicine comprising the protein or the DNA, an antibody against the protein, a method/kit for screening for a compound or a salt thereof which promotes or inhibits the protease activity or the extracellular metric degrading enzyme activity (preferably, the peptidoglycan degrading enzyme activity) of the protein, a compound obtained by the screening, and a medicine comprising the compound. The present protein and a DNA encoding it can be used, for example, as an agent for treating or preventing various diseases such as disc herniation, ischialgia, glomerular nephritis, diabetic nephropathy, hepatic fibrosis, pulmonary fibrosis or osteopetrosis. In addition, the present antibody can be used for quantitating the present protein in a test solution. Further, the present protein is useful as a reagent for screening for a compound which promotes or inhibits the protease activity of the present protein.
公开/授权文献
- US07144720B2 Protein and DNA thereof 公开/授权日:2006-12-05