发明申请
US20050187282A1 Condensed indoline derivatives and their use as 5HT, in particular 5HT2c, receptor ligands
失效
缩合二氢吲哚衍生物及其用作5HT,特别是5HT2c受体配体
- 专利标题: Condensed indoline derivatives and their use as 5HT, in particular 5HT2c, receptor ligands
- 专利标题(中): 缩合二氢吲哚衍生物及其用作5HT,特别是5HT2c受体配体
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申请号: US11117459申请日: 2005-04-29
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公开(公告)号: US20050187282A1公开(公告)日: 2005-08-25
- 发明人: Jonathan Roffey , James Davidson , Howard Mansell , Richard Hamlyn , David Adams
- 申请人: Jonathan Roffey , James Davidson , Howard Mansell , Richard Hamlyn , David Adams
- 专利权人: VERNALIS RESEARCH LIMITED
- 当前专利权人: VERNALIS RESEARCH LIMITED
- 优先权: GB9918965.6 19990811
- 主分类号: C07D491/048
- IPC分类号: C07D491/048 ; A61K31/4045 ; A61K31/407 ; A61K31/4745 ; A61P1/04 ; A61P3/04 ; A61P7/02 ; A61P9/10 ; A61P25/04 ; A61P25/06 ; A61P25/08 ; A61P25/14 ; A61P25/18 ; A61P25/22 ; A61P25/24 ; A61P25/28 ; A61P25/30 ; A61P43/00 ; C07D209/60 ; C07D209/70 ; C07D471/04 ; C07D491/04 ; C07D491/056 ; C07D495/04 ; A61K31/403 ; C07D209/56
摘要:
A chemical compound of formula (I) wherein R1 and R2 are independently selected from hydrogen and alkyl; R3 is alkyl; R4 and R5 are selected from hydrogen and alkyl; R6 and R7 are independently selected from hydrogen, halogen, hydroxyl, alkyl, aryl, amino, alkylamino, dialkylamino, alkoxy, aryloxy, alkylthio, alkylsulfoxyl, nitro, carbonitrile, carbo-alkoxy, carbo-aryloxy and carboxyl; and A is a 5- or 6-membered ring optionally containing one or more heteroatoms wherein the atoms of the ring A, other than the unsaturated carbon atoms of the phenyl ring to which the ring A is fused, are saturated or unsaturated, and pharmaceutically acceptable salts, addition compounds and prodrugs thereof; and the use thereof in therapy, particularly as an agonist or antagonist of a 5HT receptor, particularly a 5HT2C receptor, for instance in the treatment of disorders of the central nervous system; damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders; diabetes insipidus, and sleep apnea, and particularly for the treatment of obesity.