发明申请
- 专利标题： Tim-3 ligands and methods thereof
- 专利标题（中）： Tim-3配体及其方法
-
申请号： US10958169申请日： 2004-10-04
-
公开(公告)号： US20050191721A1公开(公告)日： 2005-09-01
- 发明人: Vijay Kuchroo , Terry Strom , Eugene Cha , Sumone Chakravarti , Catherine Sabatos , Chen Zhu , Xin Zheng , Alberto Sanchez-Fueyo
- 申请人： Vijay Kuchroo , Terry Strom , Eugene Cha , Sumone Chakravarti , Catherine Sabatos , Chen Zhu , Xin Zheng , Alberto Sanchez-Fueyo
- 申请人地址： US MA Boston US MA Boston
- 专利权人： Brigham and Women's Hospital,Beth Israel Deaconess Medical Center
- 当前专利权人： Brigham and Women's Hospital,Beth Israel Deaconess Medical Center
- 当前专利权人地址： US MA Boston US MA Boston
- 主分类号： C07H21/04
- IPC分类号： C07H21/04 ; C07K14/47 ; C07K14/705 ; C07K16/18 ; C07K16/28 ; C12N5/06
摘要：
The invention relates to isolated polypeptides and nucleic acids encoding polypeptides which comprise a tim-3 IgV domain and a tim-3 intracellular domain, wherein the polypeptides do not comprise a tim-3 mucin domain or a tim-3 transmembrane domain. In addition, the invention relates to methods of modulating immune responses in a subject, comprising administering to the subject a therapeutically effective amount of an agent that modulates tim-3 activity. Immune responses include, but are not limited to, immune tolerance, transplantation tolerance, Th1 responses and Th2 responses.
公开/授权文献
- US08329660B2 Tim-3 ligands and methods thereof 公开/授权日：2012-12-11
信息查询
