发明申请
US20050192336A1 (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione:methods of using and compositions thereof
有权
（+） - 2- [1-（3-乙氧基-4-甲氧基苯基）-2-甲基磺酰基乙基] -4-乙酰氨基异二氢吲哚-1,3-二酮的制备方法及其组合物
![(+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione:methods of using and compositions thereof](/docs/US/2005-09-01/US20050192336A1/abs.jpg.600x600.jpg)
- 专利标题： (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione:methods of using and compositions thereof
- 专利标题（中）： （+） - 2- [1-（3-乙氧基-4-甲氧基苯基）-2-甲基磺酰基乙基] -4-乙酰氨基异二氢吲哚-1,3-二酮的制备方法及其组合物
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申请号： US11106142申请日： 2005-04-13
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公开(公告)号： US20050192336A1公开(公告)日： 2005-09-01
- 发明人: George Muller , Peter Schafer , Hon-Wah Man , Chuansheng Ge
- 申请人： George Muller , Peter Schafer , Hon-Wah Man , Chuansheng Ge
- 主分类号： A61K45/00
- IPC分类号： A61K45/00 ; A61K31/4035 ; A61P1/04 ; A61P11/00 ; A61P11/06 ; A61P17/00 ; A61P17/06 ; A61P19/02 ; A61P25/24 ; A61P29/00 ; A61P35/00 ; A61P35/02 ; A61P43/00 ; C07C317/28 ; C07D209/48
![(+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione:methods of using and compositions thereof](/abs-image/US/2005/09/01/US20050192336A1/abs.jpg.150x150.jpg)
摘要：
Stereomerically pure (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, substantially free of its (−) isomer, and prodrugs, metabolites, polymorphs, salts, solvates, hydrates, and clathrates thereof are discussed. Also discussed are methods of using and pharmaceutical compositions comprising the (+) enantiomer of 2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione are disclosed. The methods include methods of treating and/or preventing disorders ameliorated by the reduction of levels of TNF-α or the inhibition of PDE4.
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