发明申请
- 专利标题： Polymorphic forms of sertraline hydrochloride
- 专利标题（中）： 盐酸舍曲林的多形态
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申请号： US11101860申请日： 2005-04-08
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公开(公告)号： US20050197404A1公开(公告)日： 2005-09-08
- 发明人: Paul Van Der Schaaf , Franz Schwarzenbach , Hans Kirner , Martin Szelagiewicz , Claudia Marcolli , Andreas Burkhard
- 申请人： Paul Van Der Schaaf , Franz Schwarzenbach , Hans Kirner , Martin Szelagiewicz , Claudia Marcolli , Andreas Burkhard
- 优先权： EP99810981.3 19991029
- 主分类号： A61K31/135
- IPC分类号： A61K31/135 ; A61K31/137 ; C07C211/42
摘要：
Sertraline hydrochloride polymorphic form II is conveniently prepared by adding hydrogen chloride to solution of sertraline free amine in a ketone. In preferred processes, the solution of sertraline free amine seeded with some crystals of polymorphic form II and/or the solution is heated before addition of the hydrogen chloride.
公开/授权文献
- US07442838B2 Polymorphic forms of sertraline hydrochloride 公开/授权日：2008-10-28
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