发明申请
- 专利标题: Bicyclic amides
- 专利标题(中): 双环酰胺
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申请号: US10509584申请日: 2003-04-08
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公开(公告)号: US20050203112A1公开(公告)日: 2005-09-15
- 发明人: Laurie Castonguay , William Hagmann , Linus Lin , Shrenik Shah
- 申请人: Laurie Castonguay , William Hagmann , Linus Lin , Shrenik Shah
- 国际申请: PCT/US03/10740 WO 20030408
- 主分类号: A61K31/165
- IPC分类号: A61K31/165 ; A61K31/343 ; A61K31/353 ; A61K31/36 ; A61K31/403 ; A61K31/4433 ; A61K31/454 ; A61K31/4709 ; A61K31/4745 ; A61K31/517 ; A61P1/00 ; A61P1/10 ; A61P1/16 ; A61P3/04 ; A61P9/10 ; A61P11/06 ; A61P25/00 ; A61P25/06 ; A61P25/08 ; A61P25/16 ; A61P25/18 ; A61P25/22 ; A61P25/28 ; A61P25/36 ; A61P43/00 ; C07C233/59 ; C07D209/88 ; C07D307/84 ; C07D307/85 ; C07D311/58 ; C07D311/66 ; C07D319/20 ; C07D405/12
摘要:
Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.
公开/授权文献
- US07667053B2 Bicyclic amides 公开/授权日:2010-02-23