发明申请
US20050208498A1 Methods of therapy and diagnosis using targeting of cells that express killer cell immunoglobulin-like receptor-like protein
审中-公开
使用靶向表达杀伤细胞免疫球蛋白样受体样蛋白的细胞进行治疗和诊断的方法
- 专利标题： Methods of therapy and diagnosis using targeting of cells that express killer cell immunoglobulin-like receptor-like protein
- 专利标题（中）： 使用靶向表达杀伤细胞免疫球蛋白样受体样蛋白的细胞进行治疗和诊断的方法
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申请号： US10727012申请日： 2003-12-02
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公开(公告)号： US20050208498A1公开(公告)日： 2005-09-22
- 发明人: Peter Emtage , Ping Zhou , Vinod Asundi , Y. Tang , Radoje Drmanac
- 申请人： Peter Emtage , Ping Zhou , Vinod Asundi , Y. Tang , Radoje Drmanac
- 申请人地址： US CA Sunnyvale
- 专利权人： NUVELO, Inc.
- 当前专利权人： NUVELO, Inc.
- 当前专利权人地址： US CA Sunnyvale
- 优先权： WOPCT/US01/02623 20010125; WOPCT/US01/02687 20010125
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K39/395 ; A61K47/48 ; A61K51/00 ; A61K51/10 ; C07H21/02 ; C07H21/04 ; C07K14/705 ; C07K16/28 ; C07K16/30 ; C07K16/46 ; C12Q1/68 ; G01N33/574 ; G01N33/68
摘要：
Certain cells, including types of cancer cells such as KIRHy1, are capable of expressing KIRHy1 mRNA. Targeting using KIRHy1 polypeptides, nucleic acids encoding for KIRHy1 polypeptides and anti-KIRHy1 antibodies provides a method of killing or inhibiting that growth of cancer cells that express the KIRHy1 protein. Methods of therapy and diagnosis of disorders associated with KIRHy1 protein-expressing cells, such as B cell lymphoma, are described.