发明申请
US20050208586A1 Using complement component C1q derived molecules as tracers for fluorescence polarization assays
审中-公开
使用补体成分C1q衍生的分子作为荧光偏振测定的示踪剂
- 专利标题： Using complement component C1q derived molecules as tracers for fluorescence polarization assays
- 专利标题（中）： 使用补体成分C1q衍生的分子作为荧光偏振测定的示踪剂
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申请号： US10803246申请日： 2004-03-18
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公开(公告)号： US20050208586A1公开(公告)日： 2005-09-22
- 发明人: Shanxiang Shen
- 申请人： Shanxiang Shen
- 主分类号： C07K16/46
- IPC分类号： C07K16/46 ; G01N33/53 ; G01N33/542 ; G01N33/564
摘要：
The present invention relates to polypeptides or non-polypeptides derived from C1q, a subunit of the first complement component molecule C1. These molecules bind to the C1q receptor on the Fc domain of an antibody in immune complexes (also called antigen-antibody complexes or aggregated immunoglobulins), but do not bind to free immunoglobulins. These complement component derived molecules may be used as tracer molecules for fluorescence polarization (FP). The present invention also relates to materials and methods of producing molecules for use in FP. The present invention has many applications in the areas of biosensor development for proteomics research, protein expression profiling, drug discovery, diagnosis and prognosis, monitoring therapeutic effects, environmental survey, and bio-defense.
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