发明申请
US20050209265A1 Modulating a pharmacokinetic property of a drug by administering a bifunctional molecule containing the drug
有权
通过施用含有该药物的双官能分子来调节药物的药代动力学性质
- 专利标题: Modulating a pharmacokinetic property of a drug by administering a bifunctional molecule containing the drug
- 专利标题(中): 通过施用含有该药物的双官能分子来调节药物的药代动力学性质
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申请号: US11011776申请日: 2004-12-13
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公开(公告)号: US20050209265A1公开(公告)日: 2005-09-22
- 发明人: Roger Briesewitz , Gerald Crabtree , Thomas Wandless
- 申请人: Roger Briesewitz , Gerald Crabtree , Thomas Wandless
- 主分类号: A61K47/48
- IPC分类号: A61K47/48 ; A61K31/4745
摘要:
Bifunctional molecules and methods for their use are provided. The subject bifunctional molecules are conjugates of a drug moiety and a pharmacokinetic modulating moiety, where these two moieties are optionally joined by a linking group. The bifunctional molecules are further characterized in that they exhibit at least one modulated pharmacokinetic property upon administration to a host as compared to a free drug control. The subject bifunctional molecules find use in a variety of therapeutic applications.