发明申请
US20050214297A1 Methods and compositions relating to chitinases and chitinase-like molecules and modulation of osteoclasts
审中-公开
与几丁质酶和几丁质酶样分子有关的方法和组合以及破骨细胞的调节
- 专利标题： Methods and compositions relating to chitinases and chitinase-like molecules and modulation of osteoclasts
- 专利标题（中）： 与几丁质酶和几丁质酶样分子有关的方法和组合以及破骨细胞的调节
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申请号： US11063574申请日： 2005-02-24
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公开(公告)号： US20050214297A1公开(公告)日： 2005-09-29
- 发明人: Su-Yau Mao , Wendy White
- 申请人： Su-Yau Mao , Wendy White
- 申请人地址： US MD Gaithersburg
- 专利权人： MEDIMMUNE, INC.
- 当前专利权人： MEDIMMUNE, INC.
- 当前专利权人地址： US MD Gaithersburg
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/40
摘要：
The invention relates to the novel discovery that inhibiting a C/CLP modulates (e.g., inhibits) inflammation, as well as, bone and tissue destruction in arthritis. The present invention relates to compositions and methods for the treatment of bone metabolism and connective tissue disorders and diseases (e.g., bone metabolism disorders, osteoarthritis, psoriatic arthritis, rheumatoid arthritis, and osteoporosis) by modulating (e.g., inhibiting) at least one C/CLP. In particular where the inhibition of at least one C/CLP results in the inhibition of osteoclast activity, including but not limited to, osteoclast maturation, osteoclast differentiation, osteoclast proliferation, and osteoclastogenesis. One particular embodiment of the invention relates to inhibiting the expression or activity of one or more C/CLPs.