发明申请
US20050224710A1 Method for measuring hydrophobic peptides using maldi mass spectrometer
审中-公开
使用maldi质谱仪测量疏水肽的方法
- 专利标题： Method for measuring hydrophobic peptides using maldi mass spectrometer
- 专利标题（中）： 使用maldi质谱仪测量疏水肽的方法
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申请号： US11028216申请日： 2005-01-04
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公开(公告)号： US20050224710A1公开(公告)日： 2005-10-13
- 发明人: Eiichi Matsuo , Makoto Watanabe , Noriyuki Ojima , Chikako Toda , Hiroki Kuyama , Osamu Nishimura
- 申请人： Eiichi Matsuo , Makoto Watanabe , Noriyuki Ojima , Chikako Toda , Hiroki Kuyama , Osamu Nishimura
- 优先权： JP2004-118343 20040413
- 主分类号： G01N33/68
- IPC分类号： G01N33/68 ; H01J49/16
摘要：
The present invention provides a method capable of efficiently ionizing hydrophobic peptides in MALDI-IT, MALDI-IT-TOF, and MALDI-FTICR mass spectrometers. A method of measuring a peptide with a mass spectrometer having a MALDI (Matrix Assisted Laser Desorption/Ionization) ion source, using α-cyano-3-hydroxycinnamic acid or 3-hydroxy-4-nitrobenzoic acid as a matrix. Preferably, a peptide derivatized with 2-nitrobenzenesulfenyl chloride is measured with a MALDI-IT, MALDI-IT-TOF, or MALDI-FTICR mass spectrometer. When 3-hydroxy-4-nitrobenzoic acid is used as a matrix, the matrix is preferably used as a mixed matrix in which α-cyano-4-hydroxycinnamic acid is combined.
公开/授权文献
- US1270039A Slicing-machine. 公开/授权日：1918-06-18