发明申请
- 专利标题： Decomposition inhibitor for extracellular matrix of cartilage
- 专利标题（中）： 软骨细胞外基质分解抑制剂
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申请号： US10508530申请日： 2003-03-26
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公开(公告)号： US20050227994A1公开(公告)日： 2005-10-13
- 发明人: Takefumi Gemba , Hiroyuki Okamoto , Fumihiko Watanabe
- 申请人： Takefumi Gemba , Hiroyuki Okamoto , Fumihiko Watanabe
- 专利权人： Shionogi & Co., Ltd.
- 当前专利权人： Shionogi & Co., Ltd.
- 优先权： JP2002-87330 20020327
- 国际申请： PCT/JP03/03673 WO 20030326
- 主分类号： A61P19/02
- IPC分类号： A61P19/02 ; A61P29/00 ; A61P43/00 ; C07C311/19 ; C07C311/29 ; C07C323/59 ; C07C323/67 ; C07D241/06 ; C07D241/08 ; C07D257/04 ; C07D263/32 ; C07D271/06 ; C07D277/26 ; C07D277/68 ; C07D317/56 ; C07D333/18 ; C07D333/34 ; C07D333/54 ; C07D409/04 ; C07D409/06 ; C07D413/04 ; C07D417/04 ; A61K31/496 ; A61K31/198 ; A61K31/41 ; A61K31/4245 ; A61K31/433
摘要：
It is provided that a pharmaceutical composition inhibiting cartilage extracellular matrix degradation containing a compound of the formula (I): wherein R1 is hydroxy and the like; R2 is optionally substituted lower alkyl and the like; R3 is hydrogen atom and the like; R4 is optionally substituted arylene and the like; R5 is a bond, or —C≡C— and the like; R6 is optionally substituted aryl and the like, its optically active substance, its prodrug, their pharmaceutically acceptable salt, or solvate thereof.
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